A Rare Case of a Transgender Female With Breast Implant-Associated Anaplastic Large Cell Lymphoma Treated With Radiotherapy and a Review of the Literature

J Investig Med High Impact Case Rep. 2019 Jan-Dec:7:2324709619842192. doi: 10.1177/2324709619842192.

Abstract

We are reporting a case of a 54-year-old transgender female with a history of breast augmentation with bilateral silicone implants. Seventeen years later, she presented with an enlarging right breast mass. Pathology confirmed breast implant-associated anaplastic large cell lymphoma (Ann Arbor Stage IIE, TNM Stage III BIA-ALCL). The patient underwent bilateral capsulectomy, sentinel lymph node biopsy with adjuvant CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy, and radiotherapy to the right chest, axilla, and supraclavicular lymph nodes. BIA-ALCL is a rare entity, especially in transgender females. We report this case and a review of the literature in this report.

Keywords: BIA-ALCL; radiotherapy; transgender.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols
  • Breast Implants / adverse effects*
  • Breast Neoplasms / ethnology*
  • Breast Neoplasms / etiology
  • Breast Neoplasms / therapy
  • Device Removal
  • Female
  • Humans
  • Lymph Nodes / pathology
  • Lymphoma, Large-Cell, Anaplastic / etiology*
  • Lymphoma, Large-Cell, Anaplastic / therapy
  • Male
  • Mammaplasty
  • Middle Aged
  • Neoplasm Staging
  • Radiotherapy
  • Transgender Persons*