Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk

Pediatr Infect Dis J. 2019 Jul;38(7):727-730. doi: 10.1097/INF.0000000000002357.

Abstract

Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resulted in lower hematologic toxicity without evidence of increased vertical transmission risk.

MeSH terms

  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / adverse effects
  • Drug-Related Side Effects and Adverse Reactions / epidemiology
  • Drug-Related Side Effects and Adverse Reactions / prevention & control*
  • Female
  • HIV Infections / prevention & control*
  • Hematologic Diseases / chemically induced*
  • Hematologic Diseases / epidemiology*
  • Humans
  • Infant
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical / prevention & control*
  • Male
  • Pregnancy
  • Retrospective Studies
  • Zidovudine / administration & dosage*
  • Zidovudine / adverse effects

Substances

  • Anti-HIV Agents
  • Zidovudine