Abstract
Tamoxifen induces autophagy-dependent NET formation in CGD patient neutrophils and improves their antimicrobial activity. Given the genetic defect in their ROS-generation machinery, this study highlights repurposing of tamoxifen to potentiate host defense in CGD patients.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Extracellular Traps / immunology*
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Female
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Granulomatous Disease, Chronic* / drug therapy
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Granulomatous Disease, Chronic* / immunology
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Granulomatous Disease, Chronic* / pathology
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Humans
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Male
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Neutrophils / immunology*
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Neutrophils / pathology
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Reactive Oxygen Species / immunology
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Staphylococcal Infections* / drug therapy
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Staphylococcal Infections* / immunology
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Staphylococcal Infections* / pathology
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Staphylococcus aureus / immunology*
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Tamoxifen / administration & dosage*
Substances
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Reactive Oxygen Species
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Tamoxifen