Tamoxifen restores extracellular trap formation in neutrophils from patients with chronic granulomatous disease in a reactive oxygen species-independent manner

J Allergy Clin Immunol. 2019 Aug;144(2):597-600.e3. doi: 10.1016/j.jaci.2019.04.014. Epub 2019 Apr 27.

Abstract

Tamoxifen induces autophagy-dependent NET formation in CGD patient neutrophils and improves their antimicrobial activity. Given the genetic defect in their ROS-generation machinery, this study highlights repurposing of tamoxifen to potentiate host defense in CGD patients.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Extracellular Traps / immunology*
  • Female
  • Granulomatous Disease, Chronic* / drug therapy
  • Granulomatous Disease, Chronic* / immunology
  • Granulomatous Disease, Chronic* / pathology
  • Humans
  • Male
  • Neutrophils / immunology*
  • Neutrophils / pathology
  • Reactive Oxygen Species / immunology
  • Staphylococcal Infections* / drug therapy
  • Staphylococcal Infections* / immunology
  • Staphylococcal Infections* / pathology
  • Staphylococcus aureus / immunology*
  • Tamoxifen / administration & dosage*

Substances

  • Reactive Oxygen Species
  • Tamoxifen