Abstract
Importance:
Bilateral diffuse uveal melanocytic proliferation is a rare sign of several systemic malignant neoplasms.
Observations:
A patient presenting with uveal melanocytic proliferation underwent a detailed physical examination and extensive imaging. No systemic malignant neoplasm was found. Chorioretinal biopsy was performed, and its immunohistochemical results revealed the presence of primary vitreoretinal lymphoma.
Conclusions and relevance:
This patient's results suggest that diffuse uveal melanocytic proliferation may be associated not just with systemic malignant disease, but also with primary intraocular tumors, in this case a primary vitreoretinal lymphoma.
MeSH terms
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Antimetabolites, Antineoplastic / therapeutic use
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Biomarkers, Tumor / metabolism
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Cell Proliferation*
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Female
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Fluorescein Angiography
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Humans
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Infusions, Intravenous
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Intravitreal Injections
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Lymphoma, Large B-Cell, Diffuse / drug therapy
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Lymphoma, Large B-Cell, Diffuse / metabolism
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Lymphoma, Large B-Cell, Diffuse / pathology*
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Melanocytes / pathology*
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Methotrexate / therapeutic use
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Middle Aged
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Neoplasm Proteins / metabolism
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Paraneoplastic Syndromes, Ocular / drug therapy
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Paraneoplastic Syndromes, Ocular / metabolism
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Paraneoplastic Syndromes, Ocular / pathology*
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Retinal Neoplasms / drug therapy
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Retinal Neoplasms / metabolism
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Retinal Neoplasms / pathology*
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Tomography, Optical Coherence
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Uvea / pathology*
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Visual Acuity / physiology
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Vitreous Body / drug effects
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Vitreous Body / metabolism
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Vitreous Body / pathology*
Substances
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Antimetabolites, Antineoplastic
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Biomarkers, Tumor
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Neoplasm Proteins
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Methotrexate