TOR Signaling Is Going through a Phase

Manoel Prouteau; Robbie Loewith

doi:10.1016/j.cmet.2019.04.010

TOR Signaling Is Going through a Phase

Cell Metab. 2019 May 7;29(5):1019-1021. doi: 10.1016/j.cmet.2019.04.010.

Authors

Manoel Prouteau¹, Robbie Loewith²

Affiliations

¹ Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland.
² Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland; Swiss National Centre for Competence in Research (NCCR) in Chemical Biology, University of Geneva, Sciences II, Room 3-308, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland. Electronic address: robbie.loewith@unige.ch.

PMID: 31067446
DOI: 10.1016/j.cmet.2019.04.010

Abstract

Recently in Cell, Kato et al. (2019) and Yang et al. (2019) report that reversible oxidation of multiple methionines in a region of Pbp1, the yeast paralog of ataxin-2 protein, couples metabolic redox status to phase separation of Pbp1 into liquid-like condensates. In turn, Pbp1 condensates inhibit target of rapamycin complex 1 (TORC1) signaling and thereby induce autophagy and restore metabolic homeostasis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Ataxin-2*
Carrier Proteins
Mechanistic Target of Rapamycin Complex 1
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins*
Signal Transduction

Substances

Ataxin-2
Carrier Proteins
PBP1 protein, S cerevisiae
Saccharomyces cerevisiae Proteins
Mechanistic Target of Rapamycin Complex 1