Within the thoracic cavity, the lungs are separated from the thoracic wall by the visceral and parietal pleurae. Between these two layers exists a potential space called the pleural cavity. It is clinically significant, as pathologic processes can result in fluid accumulations within this space. The pleural cavity also maintains a negative intrapleural pressure, which resists the lungs’ natural tendency to collapse and facilitates proper function during respiration.
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