Chipping Away at Blood-Brain-Barrier Modeling

John J Jamieson; Sharon Gerecht

doi:10.1016/j.stem.2019.05.014

Chipping Away at Blood-Brain-Barrier Modeling

Cell Stem Cell. 2019 Jun 6;24(6):831-832. doi: 10.1016/j.stem.2019.05.014.

Authors

John J Jamieson¹, Sharon Gerecht²

Affiliations

¹ Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.
² Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: gerecht@jhu.edu.

PMID: 31173708
DOI: 10.1016/j.stem.2019.05.014

Abstract

In this issue, Vatine et al. (2019) present a fully human blood-brain barrier chip that accurately predicts drug permeability and can be perfused with whole blood. Utilizing patient-derived tissue, they recapitulate disease-specific defects and establish a platform to advance drug screening and disease modeling.

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MeSH terms

Biological Transport
Blood-Brain Barrier*
Humans
Models, Biological
Permeability
Precision Medicine*