Cell Culture Medium Formulation and Its Implications in Cancer Metabolism

Tobias Ackermann; Saverio Tardito

doi:10.1016/j.trecan.2019.05.004

Cell Culture Medium Formulation and Its Implications in Cancer Metabolism

Trends Cancer. 2019 Jun;5(6):329-332. doi: 10.1016/j.trecan.2019.05.004. Epub 2019 May 29.

Authors

Tobias Ackermann¹, Saverio Tardito²

Affiliations

¹ Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
² Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK. Electronic address: s.tardito@beatson.gla.ac.uk.

Abstract

Historic cell culture media were designed to ensure continuous cancer cell proliferation in vitro. However, their composition does not recapitulate the nutritional environment of the tumor. Recent studies show that novel media formulations alleviate the nonphysiological constraints imposed by historic media, and lead to cell culture results that are more relevant to tumor metabolism.

Keywords: cancer metabolism; cancer models; physiological medium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Culture Techniques*
Cell Proliferation
Culture Media* / chemistry
Energy Metabolism*
Humans
Metabolic Networks and Pathways
Neoplasms / metabolism*
Neoplasms / pathology

Substances

Culture Media

Abstract

Publication types

MeSH terms

Substances

Grants and funding