DNMT3A mutations are over-represented in young adults with NPM1 mutated AML and prompt a distinct co-mutational pattern

Leukemia. 2019 Nov;33(11):2741-2746. doi: 10.1038/s41375-019-0502-0. Epub 2019 Jun 17.

Authors

Luca Vincenzo Cappelli^{1

2}, Manja Meggendorfer¹, Frank Dicker¹, Sabine Jeromin¹, Stephan Hutter¹, Wolfgang Kern¹, Torsten Haferlach¹, Claudia Haferlach¹, Alexander Höllein³

Affiliations

¹ MLL Munich Leukemia Laboratory, Munich, Germany.
² Department of Precision and Translational Medicine, Sapienza University, Rome, Italy.
³ MLL Munich Leukemia Laboratory, Munich, Germany. alexander.hoellein@mll.com.

PMID: 31209279
DOI: 10.1038/s41375-019-0502-0

No abstract available

Publication types

Letter

MeSH terms

Adult
Aged
Aged, 80 and over
DNA (Cytosine-5-)-Methyltransferases / genetics*
DNA Methyltransferase 3A
DNA Mutational Analysis
Female
Humans
Karyotype
Leukemia, Myeloid, Acute / genetics*
Male
Middle Aged
Mutation*
Nuclear Proteins / genetics*
Nucleophosmin
Phosphoproteins / genetics
Prognosis
RNA Splicing Factors / genetics
Retrospective Studies
Serine-Arginine Splicing Factors / genetics
Spliceosomes / metabolism
Young Adult

Substances

DNMT3A protein, human
NPM1 protein, human
Nuclear Proteins
Phosphoproteins
RNA Splicing Factors
SF3B1 protein, human
Nucleophosmin
SRSF2 protein, human
Serine-Arginine Splicing Factors
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A