MRI features of demyelinating disease associated with anti-MOG antibodies in adults

Marc Denève; Damien Biotti; Sofia Patsoura; Marine Ferrier; Zuzana Meluchova; Laurence Mahieu; Françoise Heran; Catherine Vignal; Romain Deschamps; Olivier Gout; Nicolas Menjot de Champfleur; Xavier Ayrignac; Clarisse Carra Dallière; Pierre Labauge; Cécile Dulau; Thomas Tourdias; Hervé Dumas; Christophe Cognard; David Brassat; Fabrice Bonneville

doi:10.1016/j.neurad.2019.06.001

MRI features of demyelinating disease associated with anti-MOG antibodies in adults

J Neuroradiol. 2019 Sep;46(5):312-318. doi: 10.1016/j.neurad.2019.06.001. Epub 2019 Jun 20.

Authors

Marc Denève¹, Damien Biotti², Sofia Patsoura³, Marine Ferrier³, Zuzana Meluchova³, Laurence Mahieu⁴, Françoise Heran⁵, Catherine Vignal⁶, Romain Deschamps⁷, Olivier Gout⁷, Nicolas Menjot de Champfleur⁸, Xavier Ayrignac⁹, Clarisse Carra Dallière⁹, Pierre Labauge⁹, Cécile Dulau¹⁰, Thomas Tourdias¹¹, Hervé Dumas³, Christophe Cognard³, David Brassat², Fabrice Bonneville¹²

Affiliations

¹ Neuroradiology department, Pierre-Paul-Riquet/Purpan university hospital, 31300 Toulouse, France. Electronic address: denevemarc@free.fr.
² Neurology department, Pierre-Paul Riquet/Purpan university hospital, 31300 Toulouse, France.
³ Neuroradiology department, Pierre-Paul-Riquet/Purpan university hospital, 31300 Toulouse, France.
⁴ Ophthalmology department, Pierre-Paul Riquet/Purpan university hospital, 31300 Toulouse, France.
⁵ Radiology department, fondation A.-De Rothschild, 75019 Paris, France.
⁶ Ophthalmology department, fondation A.-De Rothschild, 75019 Paris, France.
⁷ Neurology department, fondation A.-De Rothschild, 75019 Paris, France.
⁸ Neuroradiology department, CHU de Montpellier, 34295 Montpellier, France.
⁹ Neurology department, CHU de Montpellier, 34295 Montpellier, France.
¹⁰ Neurology department, CHU de Bordeaux, 33000 Bordeaux, France.
¹¹ Neuroradiology department, CHU de Bordeaux, 33000 Bordeaux, France.
¹² Neuroradiology department, Pierre-Paul-Riquet/Purpan university hospital, 31300 Toulouse, France. Electronic address: bonneville.f@chu-toulouse.fr.

PMID: 31228536
DOI: 10.1016/j.neurad.2019.06.001

Abstract

The spectrum of Myelin Oligodendrocytes Glycoprotein (MOG) antibody disease constitutes a recently described challenging entity, referring to a relatively new spectrum of autoimmune disorders with antibodies against MOG predominantly involving the optic nerve and spinal cord. The purpose of this article is to describe MRI features of MOG-AD involvement in the optic nerves, spinal cord and the brain of adults.

Keywords: AQP4-IgG; MOG-AD; MOG-IgG; MRI; NMOSD; Neuromyelitis Optica.

Publication types

Review

MeSH terms

Adolescent
Adult
Autoantibodies
Brain / diagnostic imaging
Brain / pathology
Demyelinating Diseases / diagnostic imaging*
Demyelinating Diseases / immunology
Demyelinating Diseases / pathology*
Encephalitis / diagnostic imaging
Encephalitis / immunology
Encephalitis / pathology
Female
Humans
Magnetic Resonance Imaging*
Male
Myelin-Oligodendrocyte Glycoprotein / immunology
Myelitis / diagnostic imaging
Myelitis / immunology
Myelitis / pathology
Optic Nerve / diagnostic imaging
Optic Nerve / pathology
Optic Neuritis / diagnostic imaging
Optic Neuritis / immunology
Optic Neuritis / pathology
Spinal Cord / diagnostic imaging
Spinal Cord / pathology
Young Adult

Substances

Autoantibodies
MOG protein, human
Myelin-Oligodendrocyte Glycoprotein