Meningeal Memories of Viral Infection

Liliana M Sanmarco; Francisco J Quintana

doi:10.1016/j.tins.2019.06.001

Meningeal Memories of Viral Infection

Trends Neurosci. 2019 Aug;42(8):513-514. doi: 10.1016/j.tins.2019.06.001. Epub 2019 Jun 25.

Authors

Liliana M Sanmarco¹, Francisco J Quintana²

Affiliations

¹ Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: fquintana@rics.bwh.harvard.edu.

PMID: 31253444
DOI: 10.1016/j.tins.2019.06.001

Abstract

The dura mater is rich in tissue-resident macrophages originally derived from yolk sac precursors. Rua et al. (Nat. Immunol., 2019) investigated meningeal macrophages (MMs) in the context of viral infection and found that the replenishment of the MM compartment by peripheral monocytes decreases its ability to detect and respond to microbes.

Keywords: meningeal macrophages; neuroimmunology; viral infection.

Published by Elsevier Ltd.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Infections*
Macrophages
Monocytes*
Yolk Sac