Molecular Treasures of Cancer Cell Lines

Shengli Li; Zhao Zhang; Leng Han

doi:10.1016/j.molmed.2019.06.002

Molecular Treasures of Cancer Cell Lines

Trends Mol Med. 2019 Aug;25(8):657-659. doi: 10.1016/j.molmed.2019.06.002. Epub 2019 Jun 26.

Authors

Shengli Li¹, Zhao Zhang¹, Leng Han²

Affiliations

¹ Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
² Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Precision Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address: leng.han@uth.tmc.edu.

PMID: 31255475
DOI: 10.1016/j.molmed.2019.06.002

Abstract

Multifaceted characterizations of human cancer cell lines hold huge treasures for cancer research and therapeutic opportunities. Two recent publications in Nature and Nature Medicine describe the expanded Cancer Cell Line Encyclopedia (CCLE), which spans the genome, transcriptome, epigenome, proteome and metabolome, thereby providing copious resources for cancer research.

Keywords: cancer cell lines; data resources; integrative analysis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers, Tumor*
Cell Line, Tumor*
Genomics / methods
Humans
Metabolomics / methods
Proteomics / methods
Research*

Substances

Biomarkers, Tumor