Mitochondrial Homeostasis and Cellular Senescence

Panagiotis V S Vasileiou; Konstantinos Evangelou; Konstantinos Vlasis; Georgios Fildisis; Mihalis I Panayiotidis; Efstathios Chronopoulos; Panagiotis-Georgios Passias; Mirsini Kouloukoussa; Vassilis G Gorgoulis; Sophia Havaki

doi:10.3390/cells8070686

Mitochondrial Homeostasis and Cellular Senescence

Cells. 2019 Jul 6;8(7):686. doi: 10.3390/cells8070686.

Affiliations

¹ Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece.
² Department of Anatomy, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece.
³ Nursing School, National and Kapodistrian University of Athens, 123 Papadiamantopoulou Str., 11527 Athens, Greece.
⁴ Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST Newcastle, UK.
⁵ Second Department of Orthopaedics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece.
⁶ Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester MP13 9PL, UK.
⁷ Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Str., 11527 Athens, Greece.
⁸ Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece.
⁹ Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece. shavaki@med.uoa.gr.

Abstract

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.

Keywords: cellular senescence; mitochondria; mitochondrial dynamics; mitostasis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cellular Senescence*
Homeostasis
Humans
Mitochondria / metabolism*
Mitochondrial Dynamics*
Oxidative Stress / physiology
Reactive Oxygen Species / metabolism

Substances

Reactive Oxygen Species