Evolution of treatment targets in Crohn's disease

Jonathan R White; Vipul Jairath; Gordon W Moran

doi:10.1016/j.bpg.2019.02.001

Evolution of treatment targets in Crohn's disease

Best Pract Res Clin Gastroenterol. 2019 Feb-Apr:38-39:101599. doi: 10.1016/j.bpg.2019.02.001. Epub 2019 Feb 16.

Authors

Jonathan R White¹, Vipul Jairath², Gordon W Moran³

Affiliations

¹ National Institute of Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK; Nottingham Digestive Diseases Centre, The University of Nottingham, Nottingham, UK. Electronic address: jonathan.white@nottingham.ac.uk.
² Department of Medicine, Division of Gastroenterology, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. Electronic address: vjairath@uwo.ca.
³ National Institute of Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK; Nottingham Digestive Diseases Centre, The University of Nottingham, Nottingham, UK. Electronic address: Gordon.moran@nottingham.ac.uk.

PMID: 31327410
DOI: 10.1016/j.bpg.2019.02.001

Abstract

Crohn's disease is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract, associated with significantly morbidity due to both symptoms and complications that have a considerable detrimental impact on a patient's quality of life. An early treat to target approach with disease modifying agents has been shown to significantly improve long term outcomes, demonstrated by a number of therapeutic targets in a number of modalities. This review will outline the current treatment targets and measures of disease burden in Crohn's disease.

Keywords: Biomarkers; Clinician reported activity indices; Crohn’s disease; Endoscopy; Histology; Imaging; Patient reported outcomes; Treatment targets.

Publication types

Review

MeSH terms

Crohn Disease / pathology
Crohn Disease / therapy*
Humans
Quality of Life / psychology*