Assessment of cytogenetic damage in chagasic children treated with benznidazole

Mutat Res. 1988 Oct;206(2):217-20. doi: 10.1016/0165-1218(88)90163-2.

Abstract

Chromosomal aberrations and induction of micronuclei were analyzed from cultures of peripheral lymphocytes in 2 groups of chagasic children, before and after treatment with benznidazole. The median incidence of micronucleated interphase lymphocytes (20 patients) and chromosomal aberrations (10 patients) increased from control values of 5/1000 and 3% to 11.5/1000 and 6%, respectively, at a significance of P = 0.05.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Nucleus / drug effects
  • Chagas Disease / drug therapy*
  • Chagas Disease / genetics
  • Child
  • Child, Preschool
  • Chromosome Aberrations*
  • DNA Damage*
  • Female
  • Humans
  • Infant
  • Lymphocytes / cytology
  • Lymphocytes / drug effects
  • Male
  • Mutagens / adverse effects*
  • Nitroimidazoles / adverse effects*
  • Nitroimidazoles / therapeutic use
  • Trypanocidal Agents / adverse effects*

Substances

  • Mutagens
  • Nitroimidazoles
  • Trypanocidal Agents
  • benzonidazole