MEIS transcription factors in development and disease

Development. 2019 Aug 15;146(16):dev174706. doi: 10.1242/dev.174706.

Abstract

MEIS transcription factors are key regulators of embryonic development and cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed novel and surprising mechanisms by which these proteins control gene expression. This Primer summarizes recent findings about MEIS protein activity and regulation in development, and discusses new insights into the role of MEIS genes in disease, focusing on the pathogenesis of solid cancers.

Keywords: Cell cycle; Embryogenesis; Epigenetic modification of chromatin; MEIS; PBX; Post-transcriptional and posttranslational control; Solid cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Embryonic Development* / genetics
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Neoplastic
  • Homeodomain Proteins / chemistry
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / physiology
  • Humans
  • Neoplasm Proteins / genetics
  • Neoplasms / etiology
  • Neoplasms / genetics
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / physiology*

Substances

  • Homeodomain Proteins
  • Neoplasm Proteins
  • Transcription Factors