[Biological diagnosis of mature B cell malignancies]

Presse Med. 2019 Jul-Aug;48(7-8 Pt 1):816-824. doi: 10.1016/j.lpm.2019.07.021. Epub 2019 Aug 19.
[Article in French]

Abstract

Diagnosis of mature B cell malignancies is highly multidisciplinary. Biological tools provide diagnostic, prognostic and theranostic information. Biological hematology allows considering mature B cell diseases from two perspectives : cellular and molecular approaches. Cytomorphology and flow cytometry are tools from cell hematology. Conventional cytogenetics, FISH and molecular biology are tools from molecular hematology. NGS is a new technique that could dramatically change diagnostic and therapeutic management of B cell malignancies in the near future. Integration of clinical, pathological and biological data allows for personalized management of these diseases.

Publication types

  • Review

MeSH terms

  • Clinical Laboratory Techniques / methods*
  • Comparative Genomic Hybridization / methods
  • Cytodiagnosis / methods
  • Cytogenetic Analysis / methods
  • DNA Mutational Analysis / methods
  • High-Throughput Nucleotide Sequencing / methods
  • Humans
  • Immunophenotyping / methods
  • In Situ Hybridization, Fluorescence / methods
  • Leukemia, B-Cell / diagnosis*
  • Leukemia, B-Cell / genetics
  • Leukemia, B-Cell / pathology
  • Lymphoma, B-Cell / diagnosis*
  • Lymphoma, B-Cell / genetics
  • Lymphoma, B-Cell / pathology
  • Molecular Diagnostic Techniques / methods
  • Multimodal Imaging / methods
  • Multimodal Imaging / trends
  • Systems Integration*