Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses

Mark W Russell; Julie S Moldenhauer; Jack Rychik; Nancy B Burnham; Erin Zullo; Samuel I Parry; Rebecca A Simmons; Michal A Elovitz; Susan C Nicolson; Rebecca L Linn; Mark P Johnson; Sunkyung Yu; Matthew G Sampson; Hakon Hakonarson; J William Gaynor

doi:10.1016/j.dib.2019.104311

Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses

Data Brief. 2019 Jul 26:25:104311. doi: 10.1016/j.dib.2019.104311. eCollection 2019 Aug.

Authors

Affiliations

¹ Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
² Center for Fetal Diagnosis and Therapy, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
³ Division of Pediatric Cardiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁴ Division of Cardiothoracic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁵ Division of Maternal Fetal Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.
⁶ Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁷ Division of Cardiothoracic Anesthesiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁸ Division of Anatomic Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁹ Division of Pediatric Nephrology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
¹⁰ Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
¹¹ The Center for Applied Genomics, The Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article "Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects" (Russell et al., 2019).

Keywords: Congenital cardiac defects; Fetal growth; Genetic variation; Placental function.

Grants and funding

UL1 TR000003/TR/NCATS NIH HHS/United States