Advances in T-cell Immunotherapies

David F Stroncek; Opal Reddy; Steven Highfill; Sandhya R Panch

doi:10.1016/j.hoc.2019.05.006

Advances in T-cell Immunotherapies

Hematol Oncol Clin North Am. 2019 Oct;33(5):825-837. doi: 10.1016/j.hoc.2019.05.006. Epub 2019 Jul 4.

Authors

David F Stroncek¹, Opal Reddy², Steven Highfill², Sandhya R Panch²

Affiliations

¹ Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Center for Cellular Engineering, 10 Center Drive, MSC-1184, Building 10, Room 1C711, Bethesda, MD 20892-1184, USA. Electronic address: dstroncek@cc.nih.gov.
² Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Center for Cellular Engineering, 10 Center Drive, MSC-1184, Building 10, Room 1C711, Bethesda, MD 20892-1184, USA.

PMID: 31466607
DOI: 10.1016/j.hoc.2019.05.006

Abstract

Cell therapies have become an important part of clinical hematology and oncology. Cell therapy laboratories were first established in academic health centers to process ABO-incompatible marrow grafts. These laboratories now produce a wide variety of cell and gene therapies. Some of the most widely used and clinically important cell therapies are T-cell immunotherapies. These therapies include donor lymphocyte infusions, tumor-infiltrating lymphocytes, T-cell receptor-engineered T cells, chimeric antigen receptor T cells, and virus-specific T cells. The clinical application and methods used to manufacture these adoptive cell therapies are reviewed.

Keywords: Cancer immunotherapy; Cell processing; Chimeric antigen receptor T cells; Donor lymphocyte infusions; Tumor-infiltrating lymphocytes; Virus-specific T cells.

Published by Elsevier Inc.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Cell- and Tissue-Based Therapy / methods
Disease Management
Genetic Engineering
Genetic Therapy / methods
Humans
Immunotherapy, Adoptive / adverse effects
Immunotherapy, Adoptive / methods*
Immunotherapy, Adoptive / standards
Lymphocytes, Tumor-Infiltrating / immunology
Lymphocytes, Tumor-Infiltrating / metabolism
Receptors, Antigen, T-Cell / genetics
Receptors, Antigen, T-Cell / metabolism
Receptors, Chimeric Antigen / genetics
Receptors, Chimeric Antigen / metabolism
T-Cell Antigen Receptor Specificity
T-Lymphocyte Subsets / immunology
T-Lymphocyte Subsets / metabolism
T-Lymphocytes / immunology*
T-Lymphocytes / metabolism
Tissue Donors

Substances

Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen