Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis

Hum Mol Genet. 2019 Sep 15;28(18):3161-3162. doi: 10.1093/hmg/ddz141.

Erika N Guerrero^{1

2

3}, Joy Mitra¹, Haibo Wang¹, Suganya Rangaswamy¹, Pavana M Hegde¹, Priyadarshini Basu¹, K S Rao², Muralidhar L Hegde^{1

4

5}

¹ Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX 77030, USA.
² Center for Neuroscience, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of Knowledge, Republic of Panama.
³ Department of Biotechnology, Acharya Nagarjuna University, Guntur 522510, India.
⁴ Weill Medical College of Cornell University, New York, 10065, USA.
⁵ Houston Methodist Neurological Institute, Institute of Academic Medicine, Houston Methodist, Houston, TX 77030, USA.

No abstract available

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