Serum E-selectin concentration is associated with risk of metabolic syndrome in females

PLoS One. 2019 Sep 24;14(9):e0222815. doi: 10.1371/journal.pone.0222815. eCollection 2019.

Abstract

Objectives: Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and MetS were further evaluated.

Methods: A total of 205 patients were recruited from the outpatient clinics of Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria were age between 20-75 years and BMI < 35 kg/m2. Demographic, anthropometric and MetS index data were compared between genders. Markers of inflammation and endothelial dysfunction were compared between individuals with or without MetS by gender.

Results: Age-adjusted E-selectin values showed significant positive correlations with BMI, waist-hip ratio, fasting plasma glucose, systolic and diastolic blood pressure, triglycerides, TNF-α, hsCRP and ICAM-1, and inverse correlation with HDL cholesterol. E-selectin levels were positively correlated with numbers of MetS components in females (P < 0.001) but not in males (P = 0.125).

Conclusions: Increased E-selectin levels are significantly associated with increased MetS risk in females, but not in males.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Cross-Sectional Studies
  • E-Selectin / blood*
  • Female
  • Humans
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / epidemiology*
  • Middle Aged
  • Risk Assessment
  • Risk Factors
  • Sex Factors
  • Young Adult

Substances

  • Biomarkers
  • E-Selectin
  • SELE protein, human

Grants and funding

This work was supported by research grants from the Ministry of Science and Technology (MOST 104-2314-B-016-026, MOST 104-2314-B-016-053, MOST 105-2314-B-016-040-MY3) and Tri-Service General Hospital (TSGH-C104–199, TSGH-C105-005-S03, TSGH-C105-005-S04, TSGH-C105–120, TSGHC105–185, TSGH-C106-006-S01, TSGH-C106-006-S02, TSGH-C106-007-S01, TSGH-C107-005-007-S05, TSGH-C106–161, MAB-105-084) in Taiwan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.