Graphene derivatives are the new bioactive material with good physical and chemical properties and excellent biocompatibility. It has been found that graphene derivatives can improve the mechanical properties of biomaterials and promote the adhesion, proliferation and differentiation of osteoblast-related cells, so as to promote implant-bone bonding and repair of bone defects. This makes it a research hotpot in the field of bone tissue regeneration. In this paper, the mechanism of graphene derivatives promoting bone regeneration and their application in the oral field were reviewed, so as to provide theoretical basis for their application in basic and clinical research.
石墨烯衍生物具有良好的理化性能和优异的生物相容性，是一种新兴的生物活性材料。研究发现石墨烯衍生物能够改善生物材料的力学性能，并且促进成骨相关细胞的黏附、增殖和分化，从而促进种植体-骨结合和骨缺损的修复，这使其成为骨组织再生领域的研究热点。本文就石墨烯衍生物促进骨再生作用的机制及其在口腔领域的应用进行综述，为石墨烯衍生物在基础及临床研究中的应用提供理论依据。.
Keywords: Bone regeneration; Graphene oxide; Osteogenic differentiation; Reduced graphene oxide.