The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia

Francesca Gianni; Laura Belver; Adolfo Ferrando

doi:10.1101/cshperspect.a035246

The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia

Cold Spring Harb Perspect Med. 2020 Mar 2;10(3):a035246. doi: 10.1101/cshperspect.a035246.

Authors

Francesca Gianni¹, Laura Belver¹, Adolfo Ferrando^{1

2

3}

Affiliations

¹ Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA.
² Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA.
³ Department of Pediatrics, Columbia University Medical Center, New York, New York 10032, USA.

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and biological heterogeneity in this disease has already translated into new prognostic biomarkers, improved leukemia animal models, and emerging targeted therapies. This work reviews our current understanding of the molecular mechanisms of T-ALL.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / therapeutic use
Biomarkers, Tumor / genetics*
Disease Models, Animal
Gene Expression Regulation, Leukemic
Humans
Mutation
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Receptor, Notch1 / antagonists & inhibitors*
Receptor, Notch1 / genetics*
Receptor, Notch1 / metabolism

Substances

Antineoplastic Agents
Biomarkers, Tumor
NOTCH1 protein, human
Receptor, Notch1