Long non-coding RNA urothelial cancer associated 1 can regulate the migration and invasion of colorectal cancer cells (SW480) via myocardin-related transcription factor-A

Long Zhang; Chengcheng Zheng; Zhen Sun; Huaqing Wang; Fengwei Wang

doi:10.3892/ol.2019.10737

Long non-coding RNA urothelial cancer associated 1 can regulate the migration and invasion of colorectal cancer cells (SW480) via myocardin-related transcription factor-A

Oncol Lett. 2019 Oct;18(4):4185-4193. doi: 10.3892/ol.2019.10737. Epub 2019 Aug 9.

Authors

Long Zhang¹, Chengcheng Zheng¹, Zhen Sun¹, Huaqing Wang¹, Fengwei Wang¹

Affiliation

¹ Cancer Diagnosis and Treatment Center, Nankai University People's Hospital, Tianjin 300071, P.R. China.

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer-associated mortalities. Long non-coding RNAs (lncRNAs) have been identified as key regulators in the occurrence and development of CRC. The lncRNA urothelial cancer associated 1 (UCA1) has been demonstrated to promote the development of numerous different types of cancer. In the present study, a novel molecular mechanism of UCA1, regulating the migratory and invasive capabilities of SW480 CRC cells was identified. UCA1 promoted the migration and invasion of SW480 cells by suppressing phosphorylation of myocardin-related transcription factor-A (MRTF-A). Our findings indicated that UCA1 competes with extracellular signal-regulated kinases1/2 to inhibit the phosphorylation of MRTF-A. These novel discoveries may reveal additional functions of UCA1, which may support future clinical development of novel drug targets.

Keywords: colorectal cancer; invasion; migration; myocardin-related transcription factor-A; urothelial cancer associated 1.