Recent advances in transition-metal-catalyzed incorporation of fluorine-containing groups

Xiaowei Li; Xiaolin Shi; Xiangqian Li; Dayong Shi

doi:10.3762/bjoc.15.218

Recent advances in transition-metal-catalyzed incorporation of fluorine-containing groups

Beilstein J Org Chem. 2019 Sep 23:15:2213-2270. doi: 10.3762/bjoc.15.218. eCollection 2019.

Authors

Xiaowei Li^{1

2

3}, Xiaolin Shi^{1

2

3}, Xiangqian Li⁴, Dayong Shi⁴

Affiliations

¹ Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China.
² Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266000, China.
³ University of Chinese Academy of Sciences, Beijing 100049, China.
⁴ State Key Laboratory of Microbial Technology, Shandong University, 72 Binhai Road, Qingdao 266237, China.

Abstract

Fluorine chemistry plays an increasingly important role in pharmaceutical, agricultural, and materials industries. The incorporation of fluorine-containing groups into organic molecules can improve their chemical and physical properties, which attracts continuous interest in organic synthesis. Among various reported methods, transition-metal-catalyzed fluorination/fluoroalkylation has emerged as a powerful method for the construction of these compounds. This review attempts to describe the major advances in the transition-metal-catalyzed incorporation of fluorine, trifluoromethyl, difluoromethyl, trifluoromethylthio, and trifluoromethoxy groups reported between 2011 and 2019.

Keywords: C-RF bond; catalysis; fluorination; fluoroalkylation; transition metals.

Publication types

Review