Abstract
Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cell Death / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / pharmacology
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Humans
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Male
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Models, Molecular
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Molecular Structure
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Monoamine Oxidase / analysis*
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Monoamine Oxidase / metabolism
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Monoamine Oxidase Inhibitors / chemistry*
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Monoamine Oxidase Inhibitors / pharmacology
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Optical Imaging
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Photons
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Prostatic Neoplasms / diagnostic imaging*
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Prostatic Neoplasms / drug therapy
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Prostatic Neoplasms / metabolism
Substances
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Antineoplastic Agents
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Fluorescent Dyes
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Monoamine Oxidase Inhibitors
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Monoamine Oxidase