Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

Chem Commun (Camb). 2019 Oct 31;55(88):13267-13270. doi: 10.1039/c9cc07009e.

Abstract

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / pharmacology
  • Humans
  • Male
  • Models, Molecular
  • Molecular Structure
  • Monoamine Oxidase / analysis*
  • Monoamine Oxidase / metabolism
  • Monoamine Oxidase Inhibitors / chemistry*
  • Monoamine Oxidase Inhibitors / pharmacology
  • Optical Imaging
  • Photons
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / metabolism

Substances

  • Antineoplastic Agents
  • Fluorescent Dyes
  • Monoamine Oxidase Inhibitors
  • Monoamine Oxidase