Immunocheckpoint inhibitors (ICIs) activated the patients' tumor immunity to kill the tumor cell, and brought new hope to patients with tumor. However, a series of immunocheckpoint inhibitors related adverse effects (irAEs) may also occur based on immune injury. Glucocorticoids are the basis for the treatment of such irAEs. However, the usage, dosage and course of treatment of glucocorticoid in irAEs are different from those in classic autoimmune diseases. Meanwhile, long-term use of large doses of glucocorticoids may cause serious adverse effects too. In this paper, the mechanism, dosage forms, adverse effects and management of glucocorticoids are described in detail, providing references and suggestions for oncologists to apply glucocorticoids in clinical practice.
【中文题目：免疫检查点抑制剂相关毒副作用管理之激素的使用】 【中文摘要：免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）通过激活机体的肿瘤免疫杀灭肿瘤细胞，给肿瘤患者的治疗带来新的希望。然而也可引起一系列以免疫损伤为基础的免疫检查点抑制剂相关毒副反应（immune-related adverse events, irAEs）。糖皮质激素是治疗这类毒副反应的基础，而在具体治疗irAEs时，其用法、用量、疗程又与治疗经典的自身免疫性疾病有所不同。同时，大剂量的糖皮质激素的长期使用可能引起严重的不良反应，本文对激素的作用机制、剂量剂型、毒副作用及管理等方面进行详细描述，为肿瘤医生在临床实践中应用激素提供参考和建议。】 【中文关键词：免疫检查点抑制剂；免疫相关不良反应；糖皮质激素；免疫抑制】.
Keywords: Glucocorticoid; Immune checkpoint inhibitor; Immune suppressors; Immunotherapy-related adverse effects.