Exercise benefits the cardiac, autonomic and inflammatory responses to organophosphate toxicity

Jacqueline Freire Machi; Rodrigo Schmidt; Luis M Salgueiro; Filipe Fernandes Stoyell-Conti; Catarina de Andrade Barboza; Diana Rosa Hernandez; Mariana Morris

doi:10.1016/j.toxrep.2019.06.015

Exercise benefits the cardiac, autonomic and inflammatory responses to organophosphate toxicity

Toxicol Rep. 2019 Jun 26:6:666-673. doi: 10.1016/j.toxrep.2019.06.015. eCollection 2019.

Authors

Jacqueline Freire Machi^{1

2}, Rodrigo Schmidt^{1

2

3}, Luis M Salgueiro^{1

2}, Filipe Fernandes Stoyell-Conti^{1

2

4}, Catarina de Andrade Barboza^{1

2

3

4

5}, Diana Rosa Hernandez^{1

2}, Mariana Morris^{1

2}

Affiliations

¹ Institute of Neuro-Immune Medicine, Dr. Kiran C. Patel College of Osteopathic MediciNE, Nova Southeastern University, Fort Lauderdale, FL, USA.
² Miami Veterans Affairs Healthcare System, Miami, FL, USA.
³ Heart Institute (InCor), School of Medicine, University of Sao Paulo, São Paulo, SP, Brazil.
⁴ College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA.
⁵ University of Campinas, Campinas, SP, Brazil.

Abstract

The organophosphate, diisopropyl fluorophosphate (DFP), may impair cardiovascular, autonomic and immune function while exercise training is thougt to be restorative. Experiments determined effects of wheel exercise in C57B1 male mice, testing cardiovascular and autonomic function and characterization of the immunological profile. Sedentary (S) and exercise (ET) groups were treated with corticosterone (CORT) followed by injection of DFP. This model was associated with systolic and diastolic dysfunction in the S group, measured using echocardiography (ECHO). Chronic exercise ameliorated the cardiac deficit. Autonomic balance, accessed by heart rate variability (HRV), showed increased sympathetic and decreased parasympathetic modulation in S group. Autonomic balance in ET mice was not affected by DFP. Our DFP model resulted in mild neuroinflammation seen by increased IL5, IL12 and MIP2 in brain and plasma IL6 and IL1a. DFP had a negative impact on cardiac/autonomic function and inflammatory markers, effects reduced by exercise. Data suggest a beneficial effect of exercise training on the cardiovascular and autonomic responses to DFP/CORT.

Keywords: Aerobic exercise; Cardiac function; ECG; Echocardiography; Heart rate variability; Metabolism.