PTEN isoforms with dual and opposing function

Justin Taylor; Omar Abdel-Wahab

doi:10.1038/s41556-019-0405-3

PTEN isoforms with dual and opposing function

Nat Cell Biol. 2019 Nov;21(11):1306-1308. doi: 10.1038/s41556-019-0405-3.

Authors

Justin Taylor¹, Omar Abdel-Wahab²

Affiliations

¹ Leukemia Service and Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
² Leukemia Service and Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. abdelwao@mskcc.org.

Abstract

PTEN is a phosphatase that functions as a tumour suppressor by antagonizing the PI3K–AKT pathway. However, a study now demonstrates that translational variants of PTEN enable new interactions between PTEN and the COMPASS complex, identifying a new role for PTEN in modifying gene expression via COMPASS-mediated histone H3 lysine 4 methylation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Carcinogenesis*
Histone-Lysine N-Methyltransferase
Humans
Intracellular Signaling Peptides and Proteins
PTEN Phosphohydrolase*
Protein Isoforms

Substances

Intracellular Signaling Peptides and Proteins
Protein Isoforms
WDR5 protein, human
Histone-Lysine N-Methyltransferase
PTEN Phosphohydrolase
PTEN protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding