Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

Signal Transduct Target Ther. 2019 Nov 1:4:44. doi: 10.1038/s41392-019-0076-3. eCollection 2019.

Tingting Wang¹, Margaret Shatara^{2

3}, Fangbing Liu¹, Tristan Knight^{2

3}, Holly Edwards^{4

5}, Guan Wang¹, Hai Lin⁶, Yue Wang⁷, Jeffrey W Taub^{2

5}, Yubin Ge^{3

4

5}

¹ 1National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, 130021 Changchun, People's Republic of China.
² 2Division of Pediatric Hematology/Oncology, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI 48201 USA.
³ 3Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201 USA.
⁴ 4Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201 USA.
⁵ 5Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201 USA.
⁶ 6Department of Hematology and Oncology, The First Hospital of Jilin University, 130021 Changchun, People's Republic of China.
⁷ 7Department of Pediatric Hematology and Oncology, The First Hospital of Jilin University, 130021 Changchun, People's Republic of China.

No abstract available

Keywords: Drug development; Haematological cancer.

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