Resveratrol promotes HSV-2 replication by increasing histone acetylation and activating NF-κB

Biochem Pharmacol. 2020 Jan:171:113691. doi: 10.1016/j.bcp.2019.113691. Epub 2019 Nov 5.

Abstract

Resveratrol is a natural compound found in many plant species that has broad therapeutic benefits. Here, we investigated the effects of resveratrol on the replication of HSV-2. We found that resveratrol accelerated replication of HSV-2 and increased release of progeny virion. A time-of-addition study suggested that resveratrol worked primarily in the early stage of viral infection. Resveratrol regulated HSV-2 infection by increasing histone acetylation and activating NF-κB. In addition, inhibition of CDK9 activity restrained the promoting effect of resveratrol on HSV-2 infection. Altogether, our experiments revealed the regulatory effect of resveratrol and its mechanism of action on HSV-2 replication.

Keywords: CDK9; Herpes simplex virus 2; Histone acetylation; NF-κB; Resveratrol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation / drug effects
  • Animals
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Chlorocebus aethiops
  • Gene Expression Regulation, Viral / drug effects
  • HEK293 Cells
  • HeLa Cells
  • Herpesvirus 2, Human / drug effects*
  • Herpesvirus 2, Human / genetics
  • Herpesvirus 2, Human / physiology
  • Histones / metabolism*
  • Host-Pathogen Interactions
  • Humans
  • Mice
  • NF-kappa B / metabolism*
  • RAW 264.7 Cells
  • Resveratrol / chemistry
  • Resveratrol / pharmacology*
  • Vero Cells
  • Viral Envelope Proteins / genetics
  • Virus Replication / drug effects*
  • Virus Replication / genetics

Substances

  • Antioxidants
  • Histones
  • NF-kappa B
  • Viral Envelope Proteins
  • glycoprotein D-herpes simplex virus type 2
  • Resveratrol