Abstract
The selective measurement of cellular pH at specific regions is significant for the in-depth study of cell functions and pathological processes. Herein, we combined our previously developed rhodamine B-labeled cell-penetrating peptide spirolactam derivative with quantum dots to create a ratiometric nanobiosensor for the simultaneous sensing and imaging of lysosomes and extracellular pH.
MeSH terms
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Biosensing Techniques / methods
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Cadmium Compounds / chemistry
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Cadmium Compounds / toxicity
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Cell-Penetrating Peptides / chemistry*
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Cell-Penetrating Peptides / toxicity
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / toxicity
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HeLa Cells
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Humans
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Hydrogen-Ion Concentration
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Lysosomes / metabolism*
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Microscopy, Confocal / methods
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Microscopy, Fluorescence / methods
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Nanoconjugates / chemistry
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Nanoconjugates / toxicity
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Quantum Dots / chemistry*
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Quantum Dots / toxicity
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Rhodamines / chemistry
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Rhodamines / toxicity
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Selenium Compounds / chemistry
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Selenium Compounds / toxicity
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Sulfides / chemistry
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Sulfides / toxicity
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Zinc Compounds / chemistry
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Zinc Compounds / toxicity
Substances
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Cadmium Compounds
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Cell-Penetrating Peptides
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Fluorescent Dyes
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Nanoconjugates
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Rhodamines
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Selenium Compounds
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Sulfides
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Zinc Compounds
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cadmium selenide
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rhodamine B
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zinc sulfide