Splenic resection in the dog was proven to have decreased blood loss (52%), decreased operating time (44%), and decreased surgical manipulation using the SLT Contact Nd:YAG Laser System with the synthetic sapphire probe, as compared with the noncontact CO2 laser. Tissue damage and hematologic changes were minimal and equivalent in both laser systems. The overall ease of use and operating technique was subjectively better with the contact Nd:YAG laser, and the danger of scattered and reflective beam damage was eliminated. The contact Nd:YAG laser with the synthetic sapphire probes offers a significant advantage over the noncontact CO2 laser in the resection of splenic tissue. Future applications in pediatric surgery now need to be evaluated.