1 Division of Perioperative Medicine and Intensive Care, Section Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Heart and Vascular Division, Karolinska University Hospital, Stockholm, Sweden Division of Perioperative Medicine and Intensive Care, Section Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.