Gut Bacteria-Not for the Faint of Heart

Noa Mandelbaum; Tal Gefen; Naama Geva-Zatorsky

doi:10.1016/j.chom.2019.12.011

Gut Bacteria-Not for the Faint of Heart

Cell Host Microbe. 2020 Jan 8;27(1):1-3. doi: 10.1016/j.chom.2019.12.011.

Authors

Noa Mandelbaum¹, Tal Gefen¹, Naama Geva-Zatorsky²

Affiliations

¹ Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa, Israel.
² Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Technion Integrated Cancer Center (TICC), Haifa, Israel; Canadian Institute for Advanced Research (CIFAR) Azrieli Global Scholar, MaRS Centre, West Tower 661 University Ave., Suite 505, Toronto, ON M5G 1M1, Canada. Electronic address: naama_gz@technion.ac.il.

PMID: 31951820
DOI: 10.1016/j.chom.2019.12.011

Abstract

The role of gut bacteria in complications of heart inflammation has previously not been fully understood. Gil-Cruz et al. (2019) demonstrate a commensal Bacteroides species that triggers a cross-immune response against a bacterial protein and heart epitope, causing cardiomyopathy. This study links commensal bacteria with heart inflammation mechanistically in mice and correlatively in patients.

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MeSH terms

Animals
Bacteria
Bacteroides
Cardiomyopathies*
Humans
Mice
Microbiota*
Peptides

Substances

Peptides