Human Cytomegalovirus Latency and Myelosuppression: A microRNA-Dependent Yin and Yang Regulatory Loop

Lauren Gay; Rolf Renne

doi:10.1016/j.chom.2019.12.008

Human Cytomegalovirus Latency and Myelosuppression: A microRNA-Dependent Yin and Yang Regulatory Loop

Cell Host Microbe. 2020 Jan 8;27(1):8-10. doi: 10.1016/j.chom.2019.12.008.

Authors

Lauren Gay¹, Rolf Renne²

Affiliations

¹ Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA.
² Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA; University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA; University of Florida Genetics Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address: rrenne@ufl.edu.

Abstract

In this issue of Cell Host & Microbe, Hancock et al., 2020 show that latent HCMV infection, and specifically miR-US5-2, induces TGF-β secretion, which inhibits myelopoiesis in uninfected HPCs. They also show that HCMV-infected cells become resistant to TGF-β signaling through targeting of SMAD3 by miR-UL22-A-3p and -5p.

Publication types

Comment

MeSH terms

Cytomegalovirus / genetics*
Hematopoietic Stem Cells
Humans
MicroRNAs*
Transforming Growth Factor beta
Virus Latency

Substances

MicroRNAs
Transforming Growth Factor beta

Abstract

Publication types

MeSH terms

Substances

Grants and funding