Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population

Nikhil Kirtipal; Hitender Thakur; Ranbir Chander Sobti

doi:10.22099/mbrc.2019.34904.1438

Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population

Mol Biol Res Commun. 2019 Dec;8(4):167-170. doi: 10.22099/mbrc.2019.34904.1438.

Authors

Nikhil Kirtipal^{1

2}, Hitender Thakur^{1

2}, Ranbir Chander Sobti¹

Affiliations

¹ Department of Biotechnology, Panjab University, Chandigarh-160014, India.
² Department of Biotechnology, SUSCET, Tangori, Punjab-140306, India.

Abstract

This research aimed to explore the ACE (insertion/deletion) gene association as key factor for chronic obstructive pulmonary disease (COPD) development in north Indian population. A total of 200 clinically diagnosed patients with COPD were selected against 200 healthy individuals. Genetic variations of ACE (insertion/deletion) were evaluated by using polymerase chain reaction techniques. Smoker showed higher risk of COPD (OR=1.67, 95% CI=1.12-2.48, P=0.012). Present results revealed the positive association between the DD genotype and the risk of COPD (OR= 2.14, 95% CI=1.22-3.78, P=0.006). Among smokers, DD genotype showed statistically significant association with increased risk of COPD (OR=3.10, 95% CI= 1.50-6.47, P=0.001).

Keywords: ACE; COPD; Genotype; Polymorphism.