Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21

Prog Brain Res. 2020:251:181-208. doi: 10.1016/bs.pbr.2019.10.004. Epub 2019 Nov 29.

Abstract

People who have Down syndrome are at significantly elevated risk of developing early onset Alzheimer's disease that causes dementia (AD-DS). Here we review recent progress in modeling the development of AD-DS in mouse models. These studies provide insight into mechanisms underlying Alzheimer's disease and generate new clinical research questions. In addition, they suggest potential new targets for disease prevention therapies.

Keywords: Alzheimer's disease; Down syndrome; Mouse models.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease* / drug therapy
  • Alzheimer Disease* / genetics
  • Alzheimer Disease* / metabolism
  • Alzheimer Disease* / pathology
  • Animals
  • Disease Models, Animal*
  • Down Syndrome* / drug therapy
  • Down Syndrome* / genetics
  • Down Syndrome* / metabolism
  • Down Syndrome* / pathology
  • Mice