This editorial discusses the role of fecal occult blood test (FOBT) in a diagnostic workup. Utility of FOBT in colorectal cancer screening is well documented in multiple clinical trials, although there continues to be a debate (and ongoing trials) on its merit relative to other screening tests. Over the years, FOBT has seen growth in its application for assessment of symptomatic gastrointestinal disease without clear guidelines on its use in this setting. The work of Lee et al. in this edition of the journal synthesizes evidence on diagnostic utility of FOBT and provides additional rationale to stop using FOBTs for symptoms evaluation or for diagnostic testing.