Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring

Nat Commun. 2020 Mar 12;11(1):1325. doi: 10.1038/s41467-020-14781-4.

Abstract

Brain wiring is remarkably precise, yet most neurons readily form synapses with incorrect partners when given the opportunity. Dynamic axon-dendritic positioning can restrict synaptogenic encounters, but the spatiotemporal interaction kinetics and their regulation remain essentially unknown inside developing brains. Here we show that the kinetics of axonal filopodia restrict synapse formation and partner choice for neurons that are not otherwise prevented from making incorrect synapses. Using 4D imaging in developing Drosophila brains, we show that filopodial kinetics are regulated by autophagy, a prevalent degradation mechanism whose role in brain development remains poorly understood. With surprising specificity, autophagosomes form in synaptogenic filopodia, followed by filopodial collapse. Altered autophagic degradation of synaptic building material quantitatively regulates synapse formation as shown by computational modeling and genetic experiments. Increased filopodial stability enables incorrect synaptic partnerships. Hence, filopodial autophagy restricts inappropriate partner choice through a process of kinetic exclusion that critically contributes to wiring specificity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Attention
  • Autophagy*
  • Axons / physiology
  • Brain / physiology*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / cytology*
  • Drosophila melanogaster / physiology*
  • Green Fluorescent Proteins / metabolism
  • Kinetics
  • Mosaicism
  • Photoreceptor Cells, Invertebrate / metabolism
  • Proteolysis
  • Pseudopodia / physiology*
  • Synapses / physiology*
  • Synaptic Transmission / physiology

Substances

  • Drosophila Proteins
  • Green Fluorescent Proteins