Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation

J Cell Biol. 2020 Mar 2;219(3):e202001159. doi: 10.1083/jcb.202001159.

Abstract

The mechanisms of quality control for extracellular proteins are still poorly understood. In this issue, Itakura et al. (2020. J. Cell. Biol.https://doi.org/10.1083/jcb.201911126) show that upon binding to misfolded proteins, the extracellular chaperone clusterin is internalized via the heparan sulfate receptor to undergo lysosomal degradation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Clusterin*
  • Heparitin Sulfate
  • Lysosomes*
  • Proteolysis

Substances

  • Clusterin
  • Heparitin Sulfate