Prenatal resident-intruder stress decreases levels of allopregnanolone in the cortex, hypothalamus, and midbrain of males, and increases levels in the hippocampus and cerebellum of female, juvenile rat offspring

Jennifer K Torgersen; Rose Petitti; Sedric Tello; Vincent F Lembo; Cheryl A Frye

doi:10.1016/j.ynstr.2020.100214

Prenatal resident-intruder stress decreases levels of allopregnanolone in the cortex, hypothalamus, and midbrain of males, and increases levels in the hippocampus and cerebellum of female, juvenile rat offspring

Neurobiol Stress. 2020 Mar 3:12:100214. doi: 10.1016/j.ynstr.2020.100214. eCollection 2020 May.

Authors

Jennifer K Torgersen¹, Rose Petitti¹, Sedric Tello¹, Vincent F Lembo¹, Cheryl A Frye¹

Affiliation

¹ University at Albany - State University of New York, Comprehensive Neuropsychological Services, Albany, NY, 12203, USA.

Abstract

Prenatal stress (PNS) can influence behaviors associated with cognition, reward and emotional regulation, which are controlled by brain areas such as the cortex, hippocampus, hypothalamus, midbrain and cerebellum. Allopregnanolone in these regions modulates behavioral and parasympathetic effects. The current study tested whether exposing pregnant dams to 5 days of resident-intruder stress on prenatal days 15-20 for 10 min altered the levels of allopregnanolone in cortex, hypothalamus, hippocampus, midbrain, and cerebellum of male and female juvenile offspring. In cortex, hypothalamus, and midbrain of male rats exposed to prenatal stress, levels of allopregnanolone were significantly lower compared to all other groups. In the hippocampus and cerebellum, among females exposed to prenatal stress levels were significantly higher compared to all other groups. These differences in allopregnanolone levels varying by prenatal stress, sex and brain regions provide insight in potential mechanism of stress regulation and etiopathophysiology of stress-related disorders.

Keywords: Chronic stress; Corticosterone; Dopamine; Microdialysis; Rat; Spatial memory.