Abstract
1. The effects of oxodipine, a new dihydropyridine, were studied and compared with those of nifedipine in guinea-pig ileum. 2. Oxodipine and nifedipine, 10(-8)-10(-7) M, produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine and histamine. 3. From these experiments it is concluded that oxodipine like nifedipine produced a similar and potent inhibitory effect of the contractile responses induced in guinea-pig ileum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholine / pharmacology
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Animals
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Calcium / pharmacology
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Calcium Channel Blockers / pharmacology*
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Dihydropyridines / pharmacology*
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Electric Stimulation
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Guinea Pigs
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Histamine / pharmacology
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Ileum / drug effects
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Ileum / physiology
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In Vitro Techniques
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects*
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Muscle, Smooth / physiology
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Nifedipine / pharmacology*
Substances
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Calcium Channel Blockers
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Dihydropyridines
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Histamine
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oxodipine
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Nifedipine
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Acetylcholine
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Calcium