Effects of glutathione S-transferase M1 and T1 deletions on Parkinson's disease risk among a North African population

A Rebai; C Chbili; S Ben Amor; A Hassine; S Ben Ammou; S Saguem

doi:10.1016/j.neurol.2020.03.013

Effects of glutathione S-transferase M1 and T1 deletions on Parkinson's disease risk among a North African population

Rev Neurol (Paris). 2021 Mar;177(3):290-295. doi: 10.1016/j.neurol.2020.03.013. Epub 2020 Apr 29.

Authors

A Rebai¹, C Chbili², S Ben Amor³, A Hassine³, S Ben Ammou³, S Saguem²

Affiliations

¹ Metabolic Biophysics and Applied Pharmacology, Laboratory, Department of Biophysics, Faculty of Medicine Sousse, Sousse University, Sousse 4002, Tunisia; Faculty of Physical and Natural Mathematical Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia. Electronic address: amalrebai89@gmail.com.
² Metabolic Biophysics and Applied Pharmacology, Laboratory, Department of Biophysics, Faculty of Medicine Sousse, Sousse University, Sousse 4002, Tunisia.
³ Neurology Department of the University Hospital Center (UHC) Sahloul, Sousse University, Sousse 4002, Tunisia.

PMID: 32359946
DOI: 10.1016/j.neurol.2020.03.013

Abstract

Purpose: In this study, the effects of glutathione S-transferase polymorphisms Mu1 (GSTM1) and glutathione S-transferase polymorphisms Theta1 (GSTT1) on Parkinson's disease (PD) risk factor were evaluated in a Tunisian population.

Methods: These polymorphisms were analyzed in 229 healthy Tunisian subjects and 64 Tunisian patients with PD, using a polymerase chain reaction (PCR). Statistical analysis was performed using SPSS 18.0. The relative associations between the GST genotypes and PD were assessed by calculating the odds ratios (ORs) and 95% confidence intervals (CIs).

Results: The study results demonstrated that the individuals with GSTM1 [OR=3.93, 95% CI: 1.98-7.92, P=10^-6] and GSTT1 [OR=5.45, 95% CI: 2.90-10.30, p=10^-6] were statistically associated with the risk of PD. A significant association was also found between the individuals with both GSTM1/T1 null genotypes and PD risk [OR=22.10, 95% CI: 6.99-73.75, P=10^-6].

Conclusion: These genotyping findings suggest that the absence of both GSTM1 and GSTT1 activity could be a contributory factor for the development of PD.

Keywords: Genetic polymorphisms; Glutathione S-transferase M1; Glutathione S-transferase T1; Parkinson's disease.

MeSH terms

Genetic Predisposition to Disease
Glutathione Transferase
Humans
Parkinson Disease*
Polymorphism, Genetic

Substances

glutathione S-transferase T1
Glutathione Transferase
glutathione S-transferase M1