Once upon a dish: engineering multicellular systems

Development. 2020 May 4;147(9):dev188573. doi: 10.1242/dev.188573.

Abstract

In February 2020, the European Molecular Biology Laboratory (EMBL) and the Institute for Bioengineering of Catalonia (IBEC) joined forces to unite researchers from all over the globe to discuss emerging topics in 'Engineering Multicellular Systems'. As we review here, key themes that arose throughout the meeting included the ethics of organoids in developmental biology, bottom-up versus top-down models, tissue organizing principles, and the future of improving these systems to better mimic the natural world.

Keywords: Embryoids; Morphogenesis; Organ-on-chip; Patterning; Signaling; Synthetic embryos; Vascularization.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bioengineering / methods*
  • Developmental Biology / methods
  • Humans
  • Organoids
  • Synthetic Biology / methods*
  • Tissue Engineering / methods