Characterization and therapeutic applications of mesenchymal stem cells for regenerative medicine

Jie Wang; Zhuo Chen; Meiyan Sun; Huijing Xu; Yufei Gao; Jingwen Liu; Miao Li

doi:10.1016/j.tice.2020.101330

Characterization and therapeutic applications of mesenchymal stem cells for regenerative medicine

Tissue Cell. 2020 Jun:64:101330. doi: 10.1016/j.tice.2020.101330. Epub 2020 Jan 10.

Authors

Jie Wang¹, Zhuo Chen², Meiyan Sun³, Huijing Xu³, Yufei Gao², Jingwen Liu⁴, Miao Li⁵

Affiliations

¹ Department of Neurology, The China-Japan Union Hospital, Jilin University, Changchun 130033, China; Jilin Province Neuro-oncology Engineering Laboratory, Jilin University, Changchun 130033, China.
² Department of Neurosurgery, The China-Japan Union Hospital, Jilin University, Changchun 130033, China; Jilin Province Neuro-oncology Engineering Laboratory, Jilin University, Changchun 130033, China; Jilin Provincial Key Laboratory of Neuro-oncology, Jilin University, Changchun 130033, China.
³ Medical Examination College, Jilin Medical University, Jilin, 132013, China.
⁴ Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77030, USA.
⁵ Department of Neurosurgery, The China-Japan Union Hospital, Jilin University, Changchun 130033, China; Jilin Province Neuro-oncology Engineering Laboratory, Jilin University, Changchun 130033, China; Jilin Provincial Key Laboratory of Neuro-oncology, Jilin University, Changchun 130033, China. Electronic address: limiao@jlu.edu.cn.

PMID: 32473704
DOI: 10.1016/j.tice.2020.101330

Abstract

Background: Mesenchymal stem cells (MSCs) are multipotent, genomic stable, self-renewable, and culturally expandable adult stem cells. MSCs facilitate tissue development, maintenance and repair, and produce secretory factors that support engraftment and trophic functions, marking them an attractive option in cell therapy, regenerative medicine and tissue engineering.

Method: In this review, we summarize the recent researches regarding the isolation and characterization of MSCs, therapeutic applications and advanced engineering techniques. We also discuss the advantages and limitations that remain to be overcome for MSCs based therapy.

Results: It has been demonstrated that MSCs are able to modulate endogenous tissue and immune cells. Preclinical studies and early phase clinical trials have shown their great potential for tissue engineering of bone, cartilage, marrow stroma, muscle, fat, and other connective tissues.

Conclusions: MSC-based therapy show considerable promise to rebuild damaged or diseased tissues, which could be a promising therapeutic method for regeneration medicine.

Keywords: Cell; Cell-based therapy; Mesenchymal stem cells (MSC); Therapy; Tissue engineering.

Publication types

Review

MeSH terms

Adult Stem Cells
Bone and Bones / pathology
Cardiovascular Abnormalities / therapy
Cell Differentiation
Humans
Inflammation / therapy
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells* / cytology
Mesenchymal Stem Cells* / immunology
Mesenchymal Stem Cells* / metabolism
Regenerative Medicine / methods*
Tissue Engineering