Abstract
Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied. The PPD corona reduced binding of specific opsonins and increased the adsorption of proteins controlling cellular uptake based on their surface patches.
MeSH terms
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Adsorption
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Blood Proteins / chemistry*
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Blood Proteins / metabolism
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Catalysis
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Dendrimers / chemical synthesis
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Dendrimers / chemistry*
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Humans
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Liposomes / chemistry*
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Nanoparticles / chemistry
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Palladium / chemistry
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Polymers / chemistry
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Protein Binding
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Protein Corona / chemistry*
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Surface Properties
Substances
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Blood Proteins
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Dendrimers
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Liposomes
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Polymers
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Protein Corona
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Palladium
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polyphenylene sulfide