Blood lead and blood pressure: analysis of cross-sectional and longitudinal data from Canada

Environ Health Perspect. 1988 Jun:78:123-6. doi: 10.1289/ehp.8878123.

Abstract

Analysis of data collected during the Canada Health Survey of 1978-1979 indicated a positive relationship between blood lead and blood pressure, but so weak that the range of lead-related variation among members of the general public was estimated to be at most 3.0 mm Hg of diastolic pressure. Even so, a blood lead level in excess of the median value of 10 micrograms/dL entailed a 37% higher risk of having diastolic pressure above 90 mm Hg. In a longitudinal study of lead foundry workers, an association was found between short-term changes in an individual's blood lead level and contemporary changes in diastolic pressure; this remained significant after allowance for age (or time) trends and for effects attributable to changes in body weight. Short-term changes in urinary cadmium levels were similarly predictive of diastolic pressure.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Blood Pressure / drug effects*
  • Canada
  • Cross-Sectional Studies
  • Health Surveys
  • Humans
  • Hypertension / chemically induced*
  • Hypertension / epidemiology
  • Lead / blood*
  • Lead / pharmacology
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Occupational Diseases / epidemiology

Substances

  • Lead