Pathogen Interference: Targeting Virulence Factors to Tackle Intracellular Microbes

Michael H Lee; Sean-Paul Nuccio; Manuela Raffatellu

doi:10.1016/j.chembiol.2020.06.017

Pathogen Interference: Targeting Virulence Factors to Tackle Intracellular Microbes

Cell Chem Biol. 2020 Jul 16;27(7):765-767. doi: 10.1016/j.chembiol.2020.06.017.

Authors

Michael H Lee¹, Sean-Paul Nuccio¹, Manuela Raffatellu²

Affiliations

¹ Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
² Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA 92093, USA. Electronic address: manuelar@ucsd.edu.

PMID: 32679090
DOI: 10.1016/j.chembiol.2020.06.017

Abstract

Infections with Salmonella enterica pose a challenge for antibiotic treatment. In this issue of Cell Chemical Biology, Tsai et al. use a chemical genomics approach to identify dephostatin as an inhibitor of intracellular Salmonella virulence in vitro and in vivo by targeting the two-component systems SsrA-SsrB and PmrB-PmrA.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Bacterial Proteins / genetics
Bacterial Proteins / metabolism
Gene Expression Regulation, Bacterial*
Salmonella typhimurium / metabolism
Transcription Factors / metabolism
Virulence
Virulence Factors* / genetics

Substances

Bacterial Proteins
Transcription Factors
Virulence Factors

Grants and funding

T32 DK007202/DK/NIDDK NIH HHS/United States