A new study by Yang and colleagues has revealed that TNF-alpha regulates PANX1 levels through an NF-kB-dependent mechanism in human endothelial cells. PANX1 modulates Ca2+ influx contributing to IL-1beta production independent of purinergic signaling. These novel findings expand our understanding of TNF-alpha-mediated upregulation of IL-1beta with implications for responses to tissue injury and infection.
Keywords: IL-1beta; NF-kB; TNF-alpha; cytokines; endothelial cells; inflammation; intracellular calcium; pannexin 1; transcription.
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