PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection

Cell Calcium. 2020 Sep:90:102253. doi: 10.1016/j.ceca.2020.102253. Epub 2020 Jul 13.

Abstract

A new study by Yang and colleagues has revealed that TNF-alpha regulates PANX1 levels through an NF-kB-dependent mechanism in human endothelial cells. PANX1 modulates Ca2+ influx contributing to IL-1beta production independent of purinergic signaling. These novel findings expand our understanding of TNF-alpha-mediated upregulation of IL-1beta with implications for responses to tissue injury and infection.

Keywords: IL-1beta; NF-kB; TNF-alpha; cytokines; endothelial cells; inflammation; intracellular calcium; pannexin 1; transcription.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Connexins / metabolism*
  • Human Umbilical Vein Endothelial Cells / metabolism
  • Humans
  • Infections / metabolism*
  • Infections / pathology*
  • Inflammasomes / metabolism
  • Inflammation / metabolism*
  • Inflammation / pathology*
  • Models, Biological
  • Nerve Tissue Proteins / metabolism*
  • Signal Transduction
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Connexins
  • Inflammasomes
  • Nerve Tissue Proteins
  • PANX1 protein, human
  • Tumor Necrosis Factor-alpha

Grants and funding